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Methods of primary influencing steel and steel ingot structures
Stejskal, Marek ; Záděra, Antonín (referee) ; Blažík, Petr (advisor)
This bachelor thesis is focused on the ways of influencing metal structure during it’s solidification in the mold that leads to changes in mechanical properties. In the first part there is explained the principle of metal crystalization, it’s types and mechanisms, there is also described the issue of metal solidification in the mold. In the second part of the thesis there is a general view of methods being used for primal influencing of steel structure. The principles and ways of use for these methods in foundry industry are explained.
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Expression and purification of recombinant proteins of human Aichi virus and other kobuviruses
Ludvík, Tomáš ; Bouřa, Evžen (advisor) ; Petrvalská, Olívia (referee)
Viral 2Apro plays many important functions in the life cycle of virus. It is protease that is involved in the cleavage of the viral polyprotein in the VP1/2A region. The structure of protein contains active site, thanks to this the protein is able to bind various substrates in the host cell, which is essential for viral infection. With the help of 2Apro , the virus can bypass the host immune response and stop the production of key host proteins. Therefore, 2Apro is suitable target for antiviral intervention. In this work were prepared two recombinant proteins from Aichi virus and Coxsackievirus B3. These are viruses of the family Picornaviridae, which belong among the human pathogens that in some cases cause serious diseases. Aichi virus is the cause of gastroenteritis and Coxsackievirus B3 in the worst cases causes dilated cardiomyopathy. Cardiomyopathy leads to poor heart function due to it is enlargement and can lead to heart failure. (In Czech) Key words: recombinant proteins, 2Apro , Aichi virus, Coxsackievirus B3
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Methods of primary influencing steel and steel ingot structures
Stejskal, Marek ; Záděra, Antonín (referee) ; Blažík, Petr (advisor)
This bachelor thesis is focused on the ways of influencing metal structure during it’s solidification in the mold that leads to changes in mechanical properties. In the first part there is explained the principle of metal crystalization, it’s types and mechanisms, there is also described the issue of metal solidification in the mold. In the second part of the thesis there is a general view of methods being used for primal influencing of steel structure. The principles and ways of use for these methods in foundry industry are explained.
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